![]() This article is a concise review on fluorination of C−H bonds. The fluorination of C−H bonds: developments and perspectives. China’s flourishing synthetic organofluorine chemistry: innovations in the new millennium. This article includes important references on fluorination and fluoroalkylation. Good partnership between sulfur and fluorine: sulfur-based fluorination and fluoroalkylation reagents for organic synthesis. Modern Fluoroorganic Chemistry: Synthesis, Reactivity, Applications 2nd ed. Organofluorine Chemistry (Blackwell, 2006). Fluorine in Organic Chemistry (Blackwell, 2004). Organofluorine Compounds: Chemistry and Applications (Springer, 2000).Ĭhambers, R. (ed.) Fluorine Chemistry at the Millennium. in Organic Chemistry: Breakthroughs and Perspectives (eds Ding, K. Ueber den Holzgeist und die verschiedenen ätherartigen Verbindungen, welche er bildet. Fluorination in medicinal chemistry: methods, strategies, and recent developments. Biosynthesis of an organofluorine molecule. Chemistry for positron emission tomography: recent advances in 11C-, 18F-, 13N-, and 15O-labeling reactions. ![]() (eds) Fluorine in Pharmaceutical and Medicinal Chemistry: From Biophysical Aspects to Clinical Applications (Imperial College Press, 2012).ĭeng, X. (ed.) Fluorine in Medicinal Chemistry and Chemical Biology (Wiley-Blackwell, 2009). Bioorganic and Medicinal Chemistry of Fluorine (Wiley-Hoboken, 2008). This article comprehensively summarizes the fluorinated agrochemicals on the market.īégué, J.-P. Current contributions of organofluorine compounds to the agrochemical industry. ![]() Ogawa, Y., Tokunaga, E., Kobayashi, O., Hirai, K. Applications of fluorine in medicinal chemistry. Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001–2011). Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends and therapeutic areas. Where does the fluorine come from? A review on the challenges associated with the synthesis of organofluorine compound. Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids. Further landmark achievements are expected in the fields of fluorination and fluoroalkylation as organofluorine compounds are used increasingly in everyday applications.Ĭottet, F., Marull, M., Lefebvre, O. This Primer aims to provide an overview of state-of-the-art strategies in fluorination, trifluoromethylation, difluoromethylation and monofluoromethylation, with an emphasis on using C–H functionalization, although other strategies for fluorination and fluoroalkylation are also discussed. The past two decades have witnessed a rapid growth in fluorination and fluoroalkylation methods thanks to the development of new reagents and catalysts. Fluorination and fluoroalkylation - incorporation of a trifluoromethyl, difluoromethyl or monofluoromethyl group - are the major strategies used for the construction of carbon–fluorine bonds and fluorinated carbon–carbon bonds, respectively. Fluorinated molecules have a wide range of applications and are used as medicines, agrochemicals and refrigerants and in smartphone liquid crystal displays, photovoltaic solar cells, Teflon tapes and the coatings of textiles and buildings.
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